Drosophila Auditory Organ Genes and Genetic Hearing Defects
نویسندگان
چکیده
منابع مشابه
Drosophila Auditory Organ Genes and Genetic Hearing Defects
The Drosophila auditory organ shares equivalent transduction mechanisms with vertebrate hair cells, and both are specified by atonal family genes. Using a whole-organ knockout strategy based on atonal, we have identified 274 Drosophila auditory organ genes. Only four of these genes had previously been associated with fly hearing, yet one in five of the genes that we identified has a human cogna...
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Objective: The aim of the present research was to compare the auditory perception and verbal intelligibility in children with cochlear implant, hearing aids and normal hearing. Methods: 60 children aged 5-7 years were divided to three groups and each group contained 20 children. The first and second groups were selected ordinarily from children with cochlear implant and hearing aids by conve...
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Auditory neuropathy is a rare form of deafness characterized by an absent or abnormal auditory brainstem response with preservation of outer hair cell function. We have identified Diaphanous homolog 3 (DIAPH3) as the gene responsible for autosomal dominant nonsyndromic auditory neuropathy (AUNA1), which we previously mapped to chromosome 13q21-q24. Genotyping of additional family members narrow...
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BACKGROUND Myosin VIIA (MyoVIIA) is an unconventional myosin necessary for vertebrate audition [1]-[5]. Human auditory transduction occurs in sensory hair cells with a staircase-like arrangement of apical protrusions called stereocilia. In these hair cells, MyoVIIA maintains stereocilia organization [6]. Severe mutations in the Drosophila MyoVIIA orthologue, crinkled (ck), are semi-lethal [7] a...
متن کاملKölliker's Organ and the Development of Spontaneous Activity in the Auditory System: Implications for Hearing Dysfunction
Prior to the "onset of hearing," developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is thought to be important in retaining and refining neural connections in the absence of sound. One of the major hypotheses regarding the origin of such activity involves a group of columnar epithelial supporting cells forming Kölliker's organ...
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ژورنال
عنوان ژورنال: Cell
سال: 2012
ISSN: 0092-8674
DOI: 10.1016/j.cell.2012.06.043